So genetic variants of Human endogenous retro virus has some slight associated with MS and will please the ProfGs in their aim for the Charcot Project.
The previously reported association was confirmed in cohorts from Northern and Central Spain, but a significant effect of the opposite allele was detected in the cohort from Southern Spain. This finding, already described in the literature as “flip-flop phenomenon” where significant associations for the same disease occur at opposite alleles of the same polymorphism, has been observed. This study adds interest of HERV-Fc1 to HERV-W, HERV-H and HERV-K18 but these have not been picked up be genome association studies does this mean something missed or something else?